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Located on Via Cola di Rienzo, the hotel is situated in the elegant Prati district, home to the Vatican and Saint Peter's Basilica. Vatican City can be reached in around 15 minutes on foot and Piazza del Popolo and Piazza di Spagna are also within walking distance. The metro station Lepanto is only 500 m from the hotel. Ciampino Airport is approximately 15 km away and Leonardo da Vinci – Fiumicino Airport is about 28 km away.
86 rooms are located on 6 storeys and can be reached by a lift. Guests are warmly welcomed by multilingual staff (English, German, French) at the 24-hour reception desk in the lobby. Check-in/check-out service is available round the clock. Amenities include a baggage storage service and a safe. Wireless internet access is provided in public areas. The tour desk offers assistance with booking excursions. The hotel has a range of facilities for guests with disabilities. The hotel has wheelchair-accessible facilities. There are a number of shops as well. A garden provides extra space for rest and relaxation in the open air. Additional facilities include a TV room. Guests arriving by car can park their vehicles in the garage or in the car park (for a fee). Further services and facilities include a transfer service, 24-hour room service, a laundry service, a hairdresser, a coin-operated laundry and a hotel shuttle bus. Active guests who wish to explore the surrounding area by bike will appreciate the bicycle hire service. Bicycle storage is also available. The business centre is on hand for guests' business requirements and provides a fax machine.
Air conditioning and central heating ensure that rooms maintain comfortable temperatures. Guests can enjoy the view onto the street from a balcony or terrace. All rooms are carpeted and include a double bed or a queen-size bed. Extra beds can be requested. A safe, a minibar and a desk are also available. Additional features include a refrigerator and a mini fridge. There is also an ironing set and a trouser press. A direct dial telephone, a television with satellite/cable channels and WiFi (no extra charge) provide all the essentials for a comfortable holiday. Bathrooms are equipped with a shower, a bathtub and a bidet. A hairdryer and a telephone are available for daily use. For extra comfort in the bathrooms, guests are offered cosmetic products. Guests can also book wheelchair-friendly rooms with wheelchair-accessible bathrooms. The hotel has family rooms, non-smoking rooms and smoking rooms.
Guests can enjoy a selection of sport and entertainment options. There are many ways to relax or stay active at the hotel, including cycling/mountain biking, a gym and a spa. Children are well looked after in the kids' club.
Various dining options are available, including a restaurant with air conditioning, a breakfast room, a café and a bar. Bed and breakfast is offered as a catering option. A continental breakfast buffet and a lunch buffet are served every day. Staff are also happy to provide children's meals.

Via Cola di Rienzo 23
Check-in from 3:00 PM · check-out by 11:00 AM
Very Good
2028 reviewsUser: SuttonJewell
Trip type: Couples
Good location, Tiny Bathroom, No Storage
Double room: The hotel was clean and the beds were comfortable although the room was not huge. Bathroom was minuscule with nowhere to put toiletry bags or other items. No storage in room, no drawers etc, tiny wardrobe which resulted in us having to keep all it…
User: S5323IMgb
Trip type: Couples
Great location, but disappointing bedroom
The hotel is ideally situated if you want to walk to the Vatican and old Rome. Our bedroom (121) benefitted from a large balcony overlooking the main road, but was very small and dark with extremely limited storage space for a couple - there were not many hang…
User: davidbM9011TS
Trip type: Couples
Nice stay in Rome
Hotel was conveniently located, staff was super helpful with all aspects of the stay. Room was comfortable and the price paid was appropriate for the room. Federico Bosi, Direttore generale at Hotel Twenty One, responded to this review Dear David,thank yo…
User: Stacey H
Trip type: Business
Disappointing-I would avoid.
I would rate this hotel around 2.5 to 3 stars at best.During my stay, I experienced several issues and did raise them with reception. Unfortunately, I did not feel that my concerns were taken seriously. I requested a room change due to significant noise issues…
User: ulf76
Trip type: Friends getaway
Amazing stay!!!!!
We just came back from a 4 night stay as we had a birthday celebration. You cannot fault this hotel. On arrival we were greeted by very professional and friendly reception staff. As we were a bit early they offered to put our luggage in a holding room while we…